R & D

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Research and Development

 

Develop treatments for cardiovascular diseases

According to WHO, cardiovascular disease (CVDs), mainly heart disease and stroke, is the top cause of death globally. Statiscally, about 17.3 million people have died from CVDs in 2008, representing 30% of all global death, and over 80% of CVDs take place in low and middle income countries. Most CVDs can be prevented by control diet, tobacco use, obesity, high blood pressure, diabetes and physical activity.

Calcium plays an important role in regulating the contraction and relaxation phases of the cardiac cycle. Calcium flows into the muscle cells through tiny channels and works as a switch that allows each heart muscle fiber to slide past each other and shorten to contract. At the end of each contraction, calcium flows out of the channels to allow the muscles to relax and lengthen again. Indeed, myocardial contractility is primarily controlled by calcium cycling. When there are calcium ion cycling defects in heart, the heart is not able to adequately pump sufficient blood and it leads to heart failure, which is characterized by reduced calcium entry into cardiac muscle cells and decreased myofilament calcium sensitivity. Consequently, many health professionals have suggested that improvements in calcium cycling or sensitivity be an useful treatment of heart failure. Calcium also plays an important role in triggering timely and strong enough contraction in the cardiac muscle to circulate blood throughout the body. The cardiac muscles require calcium to contract and squeeze blood out of the heart and into the arteries in in the body. The CBHI suggest that SAC calcium plays an important role in the maintenance of cardiac function and blood circulation because SAC calcium may promote cardiac relaxation and contractility. In other words, SAC calcium helps synchronize cardiovascular muscle contraction. We are planning to examine how SAC calcium positively influence cardiac function over next few years.

Many scientists have argued that the death of brain cells following a stroke is associated with an overload of charged calcium particles or ions. As the brain does not receive enough oxygen due to reduced blood flow, it causes high levels of calcium within the brain cells. They suggest that blocking the entry of calcium ions into dying nerve cells to treat stroke is not the answer for stroke. It is required to remove calcium ions from the nerve cell in order to treat stroke. We are planning to develop SAC calcium to help remove unnecessary calcium ions from the brain cell in order to adjust calcium imbalance. Based on the recent scientific findings, measuring calcium level in the arteries gives a better indicator of likelihood of heart attack and stroke.

Recent studies shows that patients with stroke have higher levels of calcium in their arteries, especially in coronary arteries. High serum calcium level leads to calcium deposit in the body, which contribute to the development of cardiovascular diseases. The CBHI have found that SAC calcium helps correct the calcium imbalance by directing calcium to bones and excreting unnecessary calcium in the body. The CBHI will investigate the effect of SAC calcium on stroke.

Develop treatments for diabetes

According to WHO, the global prevalence of diabetes was estimated to be 9% among adults aged 18+ years. CBS News found that about 371 million people have diabetes in the world and an estimated 4 million deaths were directly caused by diabetes in 2011. WHO projects that diabetes will be the 7th leading cause of death in 2030. Already $471 billion was spent treating diabetes in 2012.

Recent studies have demonstrated that impaired fasting glucose is one of predictor of type 2 diabetes. Calcium regulates blood glucose and plays an important role in the release of insulin because calcium is an intracellular messenger that is used throughout the life cycle of an organism to control diverse biological processes. In fact, insulin secretion is a calcium dependent biological process. Calcium is needed for the release of insulin to respond to higher amounts of blood glucose.

Diabetes is a condition in which cell Ca2+ homeostasis is impaired. According to several researchers, elevated calcium is associated with insulin resistance and fasting glucose. It indicates insulin resistance and secretion depend on calcium homeostasis. Recent studies suggests that high serum calcium concentration is associated with an increased risk of type 2 diabetes. However, there is limitation in blood test because total calcium level is detected in the blood test. About 50% of calcium is protein bound in the blood and 40% is ionized calcium which is physically important.

We have undergone clinical trials for Ca2+ homeostasis. Unlike regular calcium, SAC calcium is found to help regulate calcium level in the blood. The normal range for serum calcium is 2.2~2.6 mmol/L. SAC calcium directs calcium to bones and helps kidney excrete unnecessary calcium in order to maintain calcium balance in the blood. SAC calcium is also thought to regulate blood glucose by stimulating hormones, especially secretion of insulin. In addition, a small change in serum calcium level will lead to serious health condition. Excess calcium (hypercalcemia) can cause kidney dysfunctions and dementia while calcium deficiency can cause eye damage, brittle bones and osteoporosis.

There is not a cure for type 1 diabetes except injecting insulin. CBHI will study how SAC calcium can help patients with type 1 diabetes in near future and strive to provide more effective treatment. Prevention is more important than treatment. The CBHI is planning to invent dietary supplements for prevent diabetes by developing SAC calcium.

SAC & CANCER

Over the next ten years we are planning to explore Cancer, Alzheimer’s disease, Diabetes, Cardiovascular diseases and Stem cells.

 According to Cancer research UK, cancer is a leading cause of disease worldwide. Worldwide, one in eight deaths is due to cancer and it causes more deaths than AIDS, tuberculosis and malaria combined. In 2012, there were an estimated 14.1 million new cases of cancer in the world. WHO suggests that global cancer rates could increase by 50% to 15 million by 2020.

Cancer is caused by both external factors, such as tobacco and chemicals, and internal factors such as inherited mutations and mutations that occur from metabolism. Prevention is the most important way to live a healthy life. Early detection of potential malignancies is the most treatable. Modern medical cancer treatments, such as chemotherapy and radiation therapy, are usually difficult to tolerate. They are also associated with a certain degree of risk for side effects. In fact, current cancer therapies usually focus on killing growing cells. However, normal cells are also likely to be damaged by treatments.

In 1932 Otto Warburg who won the Nobel Prize in Medicine for his discovery that cancer was anaerobic. There are many recent scientific evidence that there is the link between acidic pH and cancer. Pathogens, including cancer cell, thrive in an acidic environment due to absence of oxygen. One of the main cause of cancer is a lack of oxygen supply. Blood must always remain at an alkaline pH 7.4 in order to retain its oxygen. When people take adequate mineral consumption, the blood is supplied the crucial minerals required to maintain an alkaline pH of 7.4. However, when mineral imbalance occurs, body fluids and organs become acidic and therefore anaerobic.

Calcium is involved in almost every biological function, including feeding every cell, DNA replication and destroying oxygen robbing acid in the body fluids. Therefore, calcium is an essential mineral to control pH and thus, to prevent cancer and other degenerative diseases such as osteoporosis. Our innovative SAC calcium helps increasing the pH level in our body and by causing calcium wave to signal the body mechanism to function properly and help them find their balance in their places. We are planning to examine how SAC calcium prevent and reverse cancer through animal experimentation and clinical trials.

We will strive to invent new treatments which enhances the body’s natural ability to protect itself through the immune system, from dangers posed by cancer cells.

SAC Clinical Trials with Osteoporosis Patients.

 

 

The Four Functions of SAC

SAC as Hormone Regulator

Bone metabolism is controlled by the interaction of a number of hormones. Hormonal imbalance can wreak havoc on bone metabolism.

SAC helps triggering hormones to maintain bone metabolic balance, by signaling pituitary hormones to trigger the release of thyroid and parathyroid hormones.

SAC as Calcium Activator

About 50% of calcium in our blood is inactive. SAC’s ionization process activates inactive calcium molecules to be used in bone building by stimulating the secretion of thyroid hormone (TH), which is responsible for depositing minerals in our bones.

SAC as Calcium Navigator

Inactive calcium molecules such as protein-bound calcium do not know where to go. SAC navigates calcium to reach its ultimate destination – the bone. SAC calcium will not be deposited in the wrong places such as the kidneys or blood vessels.

SAC as Bone Mineral Re-builder

Without any side effects, SAC calcium considerably aids in the prevention and treatment of osteoporosis, thereby reducing fracture risks by significantly improving bone mineral density. Within a relatively shorter period of time, SAC helps to deposit other essential minerals from one’s diet into the bone along with calcium for healthier bones.

Amazing Absorption Rate of SAC Calcium

Anti-bonding of SAC calcium makes it hundreds of time more water soluble than conventional calcium supplements, and maximizes the calcium absorption rate by 200 times more, all because SAC is passively absorbed without requiring any biochemical energy from cells.

Outstanding Clinical Results of SAC Calcium

 SAC’s cascading effects on physiological functions of our body also activate inactive protein-bound calcium in our blood to further boost the bone formation process, resulting in a rapid increase in bone density increase. Thousands of people have experienced a clinical increase of up to 80% in bone mineral density through the revolutionary SAC Calcium Technology.

Bone density clinical result : No Match !

A regular calcium supplement is ineffective for BMD (bone mineral density).
Considering the side effects associated with it, is it worth consuming?

 

Bone Building Triggered by Supplementing with Ionized Calcium

When the calcium ion concentration rises even slightly, the thyroid gland immediately increases the secretion of calcitonin into the blood, which removes calcium from the blood plasma and deposits it as new bone.

The above process is both natural and safe, but there has simply been no way to add ionized calcium into our blood serum directly to initiate the bone formation process… until today.

The revolutionary SAC Formulation Technology has made possible what other calcium supplements and precription drugs could not achieve. Activating and sustaining the natural bone-building process through the flash of calcium ions is both safe and fast. Most people experience a significant improvement in bone density within just six months of usage, without any side effects.

The Most Effective Way to Build Bone Density : Calcium Ions Ionized Calcium Triggers Bone Formation Process Naturally

Calcium Content in Normal Blood

Almost all of your body’s calcium is stored in bone, but the tiny amount that circulates in your bloodstream is disproportionately vital to normal physiology. About half of this circulating calcium (50%) is “ionized,” which means it carries electrical charges.

Ionized calcium (Ca++) is the only physiologically active form that can be recognized by our body and absorbed into our bones by stimulating hormones, which trigger the bone formation process .

Ionized calcium in the blood is so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in the concentration of ionized calcium in the blood triggers the bone building process to take excess calcium into bones. Utilizing this process is by far the most effective and safe way to build bone density, since it follows the body’s natural bone building mechanism.

Popular Osteoporosis Prescription Drugs and their Side Effects

There are two categories of osteoporosis medication: anti-resorptive medications that slow bone loss and anabolic drugs that increase the rate of bone formation. Disrupting essential bone metabolism may lead to serious health hazards, which is why there are so many reports that osteoporosis drugs actually make bones more brittle and that people who are treated with these drugs tend to suffer more bone fractures.*

 

Ingredient Increases Bone Mass Density (BMD)? Physiological Function Prerequisite Side Effects
Fosamax® Bisphosphonates (Alendronate Sodium) ?% In ? years Retains old bone mass by killing osteoclasts.** Calcium Blood in stool and urine, fatigue, stomach ulcers, nausea, hair loss, headache, blurred vision, heartburn, etc.
Actonel® Bisphosphonates (Risedronate Sodium) No or ? In 5 or 10years Retains old bone mass by killing osteoclasts. Calcium Pain swallowing, back pain, ulcers in stomach esophagus, joint pain, constipation, weight gain, hair loss, etc.
Boniva® Bisphosphonates(Ibandronate Sodium) No or ? In 5 or 10years Retains old bone mass by killing osteoclasts. Calcium Severe pain in bone, joint and muscle, very bad heartburn, difficulty swallowing, diarrhea, chest pain and etc.
Evista® Raloxifene No or ? In 5 or 10years Acts as an estrogen. Calcium Blood clots in the veins, hot flashes, cramps, swelling, sleep difficulty, depression, speech problems, etc.
Forteo® Teriparatide 4% in 24 months. or ? In 5 years Acts as parathyroid. Calcium Causing bone cancer in lab rats, dizziness, leg cramps, chest pain, vomiting, constipation, sluggishness, etc.
Prolia Denosumab ? In 5 years Inactivating osteoclast Calcium an Vitamin D serious allergic reactions,
low blood calcium, severe jaw bone problems,
unusual thigh bone fractures, weakens immune system, serious infections,
skin problems, and severe bone, joint, or muscle pain
Reclast Bisphosphonate(Zoledronic Acid) ? In 5 years Retains old bone mass by killing osteoclasts.** Calcium unusual fractures of the upper femur, unusual ache or pain in your hip or thigh bone
Fortical Calcitonin-Salmon ? In 5 years calcitonin – a polypeptide hormone thyroid gland runny nose, headache, back pain and nosebleed (epistaxis). Injectable calcitonin may cause an allergic reaction and unpleasant side effects including flushing of the face and hands, urinary frequency, nausea and a skin rash. Increases your risk of developing certain types of cancer
ET or HT Hormone Therapy Estrogen Progesterone ? In 10years vaginal bleeding, breast tenderness and gallbladder disease.Endometrial cancer.

Osteoporosis Prescription Drugs are More Disappointing!

Physicians typically recommend prescription medications for the treatment of osteoporosis, but these drugs are notorious for their dangerous side effects.

These drugs are designed to “increase” bone density by retaining dead bone mass through the inhibition of osteoclasts, the cells that are responsible for natural bone resorption, which provides calcium for our body’s needs.

Our body takes calcium from bones – even at the risk of bone fractures, because of calcium’s urgent and crucial role in healthy cell replication, neurotransmission, heart functions, and endocrine functions. If our bones don’t provide the required calcium right away, many of our body functions suffer, resulting in serious conditions.

Treated with those drugs, limited space within the bones is taken up by dead or nearly-dead bone mass, preventing new bone mass from being created. As a result, bones become more fragile and vulnerable to fracture!

It won’t be a surprise to see a modest increase in density from bone scans performed on those treated with these drugs, which promotes a false sense of security based on all the useless dead bone mass being counted, preventing patients from seeking alternative treatments until it’s too late.

Bones that are more dense are NOT necessarily better bones.

Most Calcium Supplements are Ineffective and Cause Serious Side Effects

Even with a plethora of calcium supplements sold in America, incidences of osteoporosis are still on the increase. Why?

There are many problems with traditional calcium supplements, since their calcium absorption rates are usually too low to be of use.

Sources – such as from coral, plants or algae, may vary in quality, but the problem is that absorbed calcium enters our blood vessels as inactive protein-bound calcium, which our body cannot utilize directly to build up bones.*

Even worse, high calcium intake in this protein-bound form develops side effects such as acid rebound, kidney damage, vascular calcification, and mineral imbalance. For these reasons, many trained medical professionals discourage the use of calcium supplements.

* Protein calcium is only utilized after extensive exercise, in which most elderly Americans do not engage.