|Ingredient||Increases Bone Mass Density (BMD)?||Physiological Function||Prerequisite||Side Effects|
|Fosamax®||Bisphosphonates (Alendronate Sodium)||?% In ? years||Retains old bone mass by killing osteoclasts.**||Calcium||Blood in stool and urine, fatigue, stomach ulcers, nausea, hair loss, headache, blurred vision, heartburn, etc.|
|Actonel®||Bisphosphonates (Risedronate Sodium)||No or ? In 5 or 10years||Retains old bone mass by killing osteoclasts.||Calcium||Pain swallowing, back pain, ulcers in stomach esophagus, joint pain, constipation, weight gain, hair loss, etc.|
|Boniva®||Bisphosphonates(Ibandronate Sodium)||No or ? In 5 or 10years||Retains old bone mass by killing osteoclasts.||Calcium||Severe pain in bone, joint and muscle, very bad heartburn, difficulty swallowing, diarrhea, chest pain and etc.|
|Evista®||Raloxifene||No or ? In 5 or 10years||Acts as an estrogen.||Calcium||Blood clots in the veins, hot flashes, cramps, swelling, sleep difficulty, depression, speech problems, etc.|
|Forteo®||Teriparatide||4% in 24 months. or ? In 5 years||Acts as parathyroid.||Calcium||Causing bone cancer in lab rats, dizziness, leg cramps, chest pain, vomiting, constipation, sluggishness, etc.|
|Prolia||Denosumab||? In 5 years||Inactivating osteoclast||Calcium an Vitamin D||serious allergic reactions,
low blood calcium, severe jaw bone problems,
unusual thigh bone fractures, weakens immune system, serious infections,
skin problems, and severe bone, joint, or muscle pain
|Reclast||Bisphosphonate(Zoledronic Acid)||? In 5 years||Retains old bone mass by killing osteoclasts.**||Calcium||unusual fractures of the upper femur, unusual ache or pain in your hip or thigh bone|
|Fortical||Calcitonin-Salmon||? In 5 years||calcitonin – a polypeptide hormone||thyroid gland||runny nose, headache, back pain and nosebleed (epistaxis). Injectable calcitonin may cause an allergic reaction and unpleasant side effects including flushing of the face and hands, urinary frequency, nausea and a skin rash. Increases your risk of developing certain types of cancer|
|ET or HT Hormone Therapy||Estrogen Progesterone||? In 10years||vaginal bleeding, breast tenderness and gallbladder disease.Endometrial cancer.|
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The Most Effective Way to Build Bone Density : Calcium Ions Ionized Calcium Triggers Bone Formation Process Naturally
Almost all of your body’s calcium is stored in bone, but the tiny amount that circulates in your bloodstream is disproportionately vital to normal physiology. About half of this circulating calcium (50%) is “ionized,” which means it carries electrical charges.
Ionized calcium (Ca++) is the only physiologically active form that can be recognized by our body and absorbed into our bones by stimulating hormones, which trigger the bone formation process .
Ionized calcium in the blood is so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in the concentration of ionized calcium in the blood triggers the bone building process to take excess calcium into bones. Utilizing this process is by far the most effective and safe way to build bone density, since it follows the body’s natural bone building mechanism.
Popular Osteoporosis Prescription Drugs and their Side Effects
There are two categories of osteoporosis medication: anti-resorptive medications that slow bone loss and anabolic drugs that increase the rate of bone formation. Disrupting essential bone metabolism may lead to serious health hazards, which is why there are so many reports that osteoporosis drugs actually make bones more brittle and that people who are treated with these drugs tend to suffer more bone fractures.*
Osteoporosis Prescription Drugs are More Disappointing!
These drugs are designed to “increase” bone density by retaining dead bone mass through the inhibition of osteoclasts, the cells that are responsible for natural bone resorption, which provides calcium for our body’s needs.
Our body takes calcium from bones – even at the risk of bone fractures, because of calcium’s urgent and crucial role in healthy cell replication, neurotransmission, heart functions, and endocrine functions. If our bones don’t provide the required calcium right away, many of our body functions suffer, resulting in serious conditions.
Treated with those drugs, limited space within the bones is taken up by dead or nearly-dead bone mass, preventing new bone mass from being created. As a result, bones become more fragile and vulnerable to fracture!
It won’t be a surprise to see a modest increase in density from bone scans performed on those treated with these drugs, which promotes a false sense of security based on all the useless dead bone mass being counted, preventing patients from seeking alternative treatments until it’s too late.
Bones that are more dense are NOT necessarily better bones.
Most Calcium Supplements are Ineffective and Cause Serious Side Effects
Even with a plethora of calcium supplements sold in America, incidences of osteoporosis are still on the increase. Why?
There are many problems with traditional calcium supplements, since their calcium absorption rates are usually too low to be of use.
Sources – such as from coral, plants or algae, may vary in quality, but the problem is that absorbed calcium enters our blood vessels as inactive protein-bound calcium, which our body cannot utilize directly to build up bones.*
Even worse, high calcium intake in this protein-bound form develops side effects such as acid rebound, kidney damage, vascular calcification, and mineral imbalance. For these reasons, many trained medical professionals discourage the use of calcium supplements.
* Protein calcium is only utilized after extensive exercise, in which most elderly Americans do not engage.
Osteoporosis Chances Are, You May be Affected
Bone is living, growing tissue. Throughout life, our bodies are breaking down old bone cells and rebuilding new bones in a continuous cycle (bone remodeling). We gain bone by building more bone cells than we lose.
After about age 40, however, this balance is typically reversed, with bone loss occurring at a much faster rate than is replaceable, leaving our bones brittle and leading to osteoporosis with increased risks of fracture, particularly of the hip, spine, wrist and shoulder.
Losing more than 25% of bone mass is enough for a clinical diagnosis of osteoporosis. In the US, 1/3 of women and 1/4 of men have the disease, with the figure increasing each year. What may be the cause of all this?
Calcium Deficient America: Are We Not Getting Enough from Diet?
Americans today are facing a serious health issue:
More than 75% of Americans are calcium deficient. Even more shocking is the fact that calcium deficiency is responsible for nearly 150 different degenerative diseases, including obesity, arthritis, fibromyalgia, acid reflux, high cholesterol, hypertension, allergies, cancer, and even more. Unless treated immediately, we are setting ourselves up for a major health breakdown.
The stomach needs a strong acidic environment for calcium absorption from food or supplements. However, people over the age of 60 produce only 1/4 of the stomach acid they did when they were 20, leading to poor absorption of calcium. Even what is absorbed doesn’t end up in the bones, due to lack of exercise and a more sedentary life style.
Consumption of processed foods such as refined sugars and grains, sodas, fried foods and trans-fats, chemical preservatives, artificial sweeteners, and prescription drugs, creates a huge imbalance in body chemistry. As a result, a significant amount of stored calcium is leached out from the bones to restore balance, using up more calcium than the body takes in.
Joint Disease & Calcium
Joint Disease & Calcium
Arthritis is the most common and disabling chronic joint disease in the world. Nearly 350 million people worldwide suffer from arthritis, and it can afflict anyone at any time, regardless of age, gender or race.Arthritis, can occur in more than 100 different forms. However, it can be classified into two major types: osteoarthritis (degenerative) and rheumatoid arthritis (inflammatory).
Osteoarthritis is a degenerative joint disease of bone cartilage, which leads to stiffness, swelling, and pain. Some of the common causes of osteoarthritis are age, obesity, injury and joint overuse.
Rheumatoid Arthritis is an auto-immune disease in which our immune system mistakenly attacks healthy joint tissue. It causes swelling, pain and eventually joint deformities. The inflammation can spread to the surrounding tissues and damage cartilage and bones. About 21 million people are affected by this disease globally each year.
Gout & Calcium Pyrophosphate Deposition Disease (CPPD) are caused by excess uric acid and calcium salt respectively, forming crystals in joints and causing inflammation, redness and swelling. Causes are unclear, but the risk increases with age and the disease is often misdiagnosed as arthritis.
Prescription Drugs for Osteoarthritis
Won’t Cure but Only Mask Pain
The type of medicine depends on how bad your pain is. For mild to moderate pain, you can try over-the-counter pain medicine, such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen. For moderate to severe pain, you may need stronger pain medicine such as opioids.
Surgery may be an option if the pain is severe, you have lost a lot of cartilage, and other treatments haven’t helped.
The many types of surgery include arthrodesis, which fuses two bones in a damaged joint so that the joint won’t bend, arthroscopy, which may be used to smooth a rough joint surface or remove loose cartilage or bone fragments and joint replacement, which is done when other treatments haven’t worked and involves surgery to replace the ends of bones in a damaged joint.
Prescription Drugs for Rheumatoid Arthritis
Weaken the Immune System
Rheumatoid arthritis (RA) is a progressive inflammatory disease that affects the joints. It gets worse over time unless the inflammation is stopped or slowed down. Only in very rare cases does rheumatoid arthritis go into remission without treatment
These are the main types of RA medications:
Disease-modifying anti-rheumatic drugs (DMARDs), Biological response modifiers (a type of DMARD), Glucocorticoids, Nonsteroidal anti-inflammatory medications (NSAIDs), and Analgesics (painkillers).
SERIOUS SIDE EFFECTS
Many DMARDs have serious side effects such as seizures, headaches, hair loss, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice, joint pain, bloody vomit, dry cough, shortness of breath, blood in your urine, swelling of feet, confusion, and little or no urinating.
SAC Solutions for Arthritis
Cartilage is a connective tissue found in joints between bones to cushion and lubricate bone movements. When calcium is lost from the cartilage, it turns brittle and wears out.
The cartilage is made up of specialized cells called chondrocytes. Because there are no blood vessels in the cartilage to supply the chondrocytes with nutrients, nutrients must diffuse through a dense connective tissue into the core of the cartilage, resulting in slow growth and repair.
SAC ionic calcium, on the other hand, diffuses and enters directly into the damaged cartilage matrix because of its passive transport mechanism. This procedure is quick and easy, providing the solution for the condition once thought irreversible.
New studies have found that a steady state of calcium flow between cells is needed for cells to make energy properly. Above picture shows activation of inactive cells with the introduction of calcium ions from SAC.
SAC as Pain Reducer
Joint pains are caused by inflammation. SAC calcium acts as a natural tranquilizer in collagen matrix because of its alkalizing effect in the cartilage. Alkalizing reduces inflammation by strengthening immune response. Studies have shown that the flash of calcium ions initiate repair in damaged tissues.
Gout and Pseudo-gout (CPPD) occur when excessive phosphorous forms crystals of uric acid, and calcium salt deposits within joints, causing inflammation. SAC calcium dissolves crystal deposits by reducing phosphorous and LDL concentration, causing the breakdown of deposits. SAC redirects released calcium to where it belongs – our bones and cartilage matrix.
SAC as Cartilage Repairer
Cartilage has limited reparability and its damage leads to long-term pain and disability.
SAC calcium helps calcium ions permeate deep into the collagen matrix to restore its structure. SAC calcium also strengthens the muscles and bones surrounding joints to prevent further cartilage damage.
SAC as Immune System Booster
Rheumatoid arthritis occurs when the immune system wrongly attacks body tissue. Some medications mainly focus on interfering with the transmission of pain signals from the joint itself, providing only temporary pain relief.
Unlike such medications, SAC calcium helps the immune system work properly and keeps it from mistakenly attacking joints.
SIGMA ANTI-BONDING CALCIUM
SAC calcium helps protein bound calcium be ionized. Calcium in serum exists in three forms-40% of calcium binding protein, 10% of inorganic calcium, and 50% of ionized calcium. Only ionized calcium is the physiologically active form and can be absorbed in our bones by stimulating hormones which trigger the activity of Osteoblast (bone forming) cells.
SAC calcium significantly restores the bone metabolism in a short period of time. As we get older, bone resorption process is more active than formation process and it results in increase of bone loss which leads to osteoporosis. SAC calcium facilitates the bone formation process.
SAC calcium maximizes calcium absorption rate 200 times higher because SAC calcium is formed with anti-bonding and can be absorbed in our body without any help from biochemical energy.
SAC(Sigma Anti-Bonding Calcium) is a calcium carbonate, that is produced in a unique process, using natural Canadian small oyster shells as essential raw material. The Calcium carbonate has a Sigma Anti-Bonding Molecule with a weak bonding force. This property makes the molecule dissolve quickly and allows it to be absorbed into cells more readily. SAC produces Active Calcium Ca++ during its metabolism in the body. SAC functions as a stimulation of the body and helps metabolism; this results in a healthier metabolic system and stronger bone structure. This property makes the molecule highly soluble and allows it to be absorbed into cells more readily. SAC produces Active Calcium Ca++ during metabolism in the body. SAC functions as a the stimulation for the body and helps metabolism, so this results in a healthier metabolic system and stronger bone structure.
Calcium carbonate does not easily dissolve in pure water (47 mg/L at normal atmospheric CO² partial pressure as shown below). The equilibrium of its solution is shown by the equation (with dissolved calcium carbonate on the right): Where the solubility product for [Ca²+][CO3²–] is given as anywhere from Ksp = 3.7×10−9 to Ksp = 8.7×10−9 at 25 °C, depending upon the data source However, SAC is more soluble in pure water, compared to normal calcium carbonate (1250mg/L at normal atmospheric CO₂ partial pressure as shown below). The equilibrium of its solution is shown by the equation (with dissolved calcium carbonate on the right):
Health and Dietary Applications
Calcium carbonate is widely used as an inexpensive calcium dietary supplement and gastric antacid, but there are many problems with intake amounts. Excessive calcium intake from supplements, fortified food and high-calcium diets can cause the milk-alkali syndrome, which involves serious toxicity and even fatalities. Calcium has been added to over-the-counter products, which also contributes to inadvertent excessive intake. This kind of excessive calcium intake can lead to hyperkalemia, which can yield complications of such as vomiting, prostate cancer, abdominal pain and altered mental status. However, Sigma anti bonding calcium carbonate can be a solution for these problems as it has a small quantity of 1/100-1/200.
Men should be aware of osteoporosis
According to the National Osteoporosis Foundation, osteoporosis is widely known as a women’s disease, but as many as one in four men in the U.S. over the age of 50 is likely to face higher risk of osteoporosis.
A recent study, which was conducted by the National Bone Health Alliance, shows that women are about three times as likely as men (53% versus 18%) to be tested using a bone-density scan after suffering a broken wrist On the other hand, the majority of male patients don’t get tested for osteoporosis after suffering a fragility fracture (fracture to the wrist, vertebrae, or other bones not caused by an accident or trauma).
An important goal is to get greater numbers of men to be tested for osteoporosis when they come to a hospital or clinic with a fracture to the wrist, vertebrae or other bones that wasn’t from a major accident or trauma.
International Osteoporosis Foundation expresses that osteoporosis is a common cause of hip fractures, and men are twice as likely as women to die in the year after suffering a broken hip.
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Neuronal and glial calcium signaling in Alzheimer’s disease
Mark P. Mattson a,b,∗, Sic L. Chana a Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center 4F01, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA b Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Received 10 May 2003; accepted 12 May 2003
Cognitive impairment and emotional disturbances in Alzheimer’s disease (AD) result from the degeneration of synapses and death of neurons in the limbic system and associated regions of the cerebral cortex. Analteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid -peptide (A) in the brain. A has been shown to cause synaptic dysfunction and can render neurons vulnerable to excitotoxicity and apoptosis by a mechanism involving disruption of cellular calcium homeostasis. By inducing membrane lipid peroxidation and generation of the aldehyde 4-hydroxynonenal,A impairs the function of membrane ion-motive ATPases and glucose and glutamate transporters, and can enhance calcium influx through voltage-dependent and ligand-gated calcium channels. Reduced levels of a secreted form of APP which normally regulates synaptic plasticity and cell survival may also promote disruption of synaptic calcium homeostasis in AD. Some cases of inherited AD are caused by mutations in presenilins 1 and 2 which perturb endoplasmic reticulum (ER) calcium homeostasis such that greater amounts of calcium are released upon stimulation, possibly as the result of alterations in IP3 and ryanodine receptor channels, Ca2+-ATPases and the ER stress protein Herp. Abnormalities in calcium regulation in astrocytes, oligodendrocytes, and microglia have also been documented in studies of experimental models of AD, suggesting contributions of these alterations to neuronal dysfunction and cell death in AD. Collectively, the available data show that perturbed cellular calcium homeostasis plays a prominent role in the pathogenesis of AD, suggesting potential benefits of preventative and therapeutic strategies that stabilize cellular calcium homeostasis.
© 2003 Elsevier Ltd. All rights reserved.
There are currently more than 4 million Americans living with Alzheimer’s disease (AD), a devastating and always fatal neurodegenerative disorder characterized by progressive impairment of cognitive function and emotional disturbances. The disease process involves the degeneration of synapses and neurons in brain regions that play fundamental roles in learning and memory including the hippocampus, entorhinal cortex, basal forebrain, amygdala, frontal cortex, and inferior parietal cortex . Two histological hallmarks of these brain regions of AD patients are the presence of aggregates of the amyloid -peptide (A) in the form of plaques, and the presence of filamentous intracellular aggregates of the microtubule-associated protein tau—the so-called neurofibrillary tangles.
∗ Corresponding author. Tel.: +1-410-558-8463; fax: +1-410-558-8465. E-mail address: email@example.com (M.P. Mattson).
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